We are still actively working on the spam issue.
National Spying Agency
The National Security Agency, or more accurately, the National Spying Agency (and sometimes comedically No Such Agency) is an American government agency that collects and harvests data to keep track of, well, everything that it can. Think of it as "Big Brother" in 1984. If the NSA wants to spy on you and collect intelligence on you, it will.
The National Spying Agency has repeatedly violated the public trust and has been spying on Americans (for profit) since at-least 1992. In 2006, it was revealed that they were using a closet in the New York AT&T building since 1998. This was long before the Snowden leaks.
The NSA has announced it will minimize its phone surveillance, as if people actually expect to believe that. The claim is that it has caused too much stress for the organization, and too much financial grief.
Making their job more difficult
See also: Anonymizing yourself
Avoiding nations participating
Snowden has released a list of countries that collaborate with the NSA. If you have any sort of webhosting or VPS, do not host it in any country listed below. There is, of course, no guarantee that countries NOT listed here are any better, but these are countries KNOWN to be problematic.
Fucking with SIGINT
If you really believe you have nothing to hide, there's a number of keywords which, if searched, could potentially put you on a secret watch-list. Knowing some agent might have to scan every one of your lengthy discussions about dragon dildos for terrorism is very satisfying.
Overiding with misinformation
Oversaturation is a good tool. Dox yourself every week with hundreds of fake information, and it can make a difference. Dox others. Purposefully act out of the ordinary. If you think you are being followed, give them a show. Act like a street performer in areas you've never been to as if you're on a hidden camera show. You are number 6 and they are number 2.